Regime change in Iran is "unacceptable" and the assassination of Supreme Leader Ayatollah Ali Khamenei would "open Pandora's box," Kremlin spokesperson Dmitry Peskov told Sky News in an interview published June 20.

Russia, which signed a strategic partnership with Iran in January, has reportedly grown increasingly alarmed as the United States weighs deeper involvement in Israel's military campaign against Tehran.

Earlier, U.S. President Donald Trump suggested the option of assassinating Iran's Supreme Leader Khamenei remains on the table, though he said the U.S. does not plan to act on it "for now."

The comment followed reporting that Israel had earlier proposed a plan to kill Khamenei — a proposal Trump initially rejected, according to a U.S. official cited by AP.

Peskov warned that any attempt at regime change in Tehran or threats to its leadership would "open Pandora's box," deepening instability across the Middle East and beyond.

"(Regime change in Iran) is unimaginable," Peskov said. "It should be unacceptable, even talking about that should be unacceptable for everyone." He added that the killing of Khamenei would promote extremist sentiment inside Iran and provoke unpredictable consequences.

"The situation is extremely tense and is dangerous not only for the region but globally," Peskov said. "An enlargement of the composition of the participants of the conflict is potentially even more dangerous. It will lead only to another circle of confrontation and escalation of tension in the region."

Russia has been a close regional ally of Iran, while Tehran supplied drones and ballistic missiles for Moscow's war against Ukraine. Meanwhile, Israel has maintained a delicate balance, refraining from joining Western sanctions against Moscow while condemning Iran's role in supporting Russia's war effort.

Asked on whether Moscow would respond to a possible strike against Khamenei, Peskov declined to specify, saying any reaction would come from "inside Iran."

Peskov also commented on Trump's dismissive response to Russian President Vladimir Putin's offer to mediate between Israel and Iran. The U.S. president reportedly told Putin to "mediate your own conflict" in reference to the Russia-Ukraine war. Peskov shrugged off the remark, calling Trump's language "unique" and urging mutual tolerance.

Tensions have risen between the U.S. and Iran following a wave of Israeli air strikes on Iranian territory, beginning June 13. The attacks targeted nuclear infrastructure and senior Iranian commanders, prompting Iranian missile strikes on Tel Aviv and other Israeli cities.

Tehran claimed that at least 224 Iranian civilians were killed on June 16, though the figures remain unverified.

Russia has offered to mediate the crisis, with Putin reportedly reaching out to both Iranian President Masoud Pezeshkian and Israeli Prime Minister Benjamin Netanyahu. Tel Aviv, according to the Kremlin, is reluctant to accept the proposal, while the EU leaders rejected it, citing Russia's aggression in Ukraine and its close military ties to Iran.

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The Kyiv IndependentYuliia Taradiuk

A meeting between Russian President Vladimir Putin and U.S. President Donald Trump is not currently on the table due to unresolved tensions in bilateral relations, Kremlin spokesperson Dmitry Peskov said in an interview with Russian state-controlled newspaper Izvestia on June 19.

The U.S. president has repeatedly floated the idea of meeting Putin, saying the Russia-Ukraine war cannot be resolved without them talking face-to-face. Nevertheless, the two have not met since Trump returned to the White House this January.

While Trump has adopted a more amicable policy toward Russia than his predecessor, U.S. ex-President Joe Biden, he has taken a more critical tone toward Moscow recently as Putin continues to reject a truce in Ukraine.

"Until the necessary 'homework' is done to remove the irritants in our relations with the United States, it makes no sense to organize a meeting," Peskov said. He added that while talks aimed at resolving these issues had begun, progress remained minimal and the key obstacles were still in place.

His remarks come just days after the Russian Foreign Ministry claimed that Washington had canceled the next round of talks to restore diplomatic relations between the two countries.

The meetings, which were expected to take place in Moscow, were part of a broader dialogue to address ongoing disputes, including Russia's war against Ukraine, and improve the functioning of each side's diplomatic missions.

Russian Foreign Ministry spokesperson Maria Zakharova said the planned round was intended to "eliminate irritants," such as staffing restrictions and banking issues for embassies. She expressed hope that the U.S. pause in talks "will not become too long."

The last two rounds of discussions, in Riyadh in February and Istanbul in April, marked the first formal diplomatic contact between the U.S. and Russia since Moscow began its full-scale invasion of Ukraine in 2022. Both sides described the Istanbul round as "constructive," though it focused largely on technical matters.

The Trump administration has so far refrained from introducing new sanctions against Russia, despite pressure from Kyiv and growing alarm in Europe over Moscow's continued refusal to agree to a ceasefire.

President Volodymyr Zelensky has repeatedly urged Washington to take a firmer stance, warning that "America's silence... only encourages Putin."

After a deadly Russian attack on Kyiv that killed 28 and injured over 130 people, Trump remained silent, with the U.S. Embassy only issuing a late statement denouncing the attack.

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The Kyiv IndependentMartin Fornusek

Israel is reluctant to accept Russia's mediation in its war with Iran, Kremlin spokesperson Dmitry Peskov said on June 17, according to the Russian state news agency TASS.

"At the moment, we see reluctance — at least on Israel’s part — to resort to mediation or pursue a peaceful resolution," Peskov claimed.  

Since June 13, Israel has repeatedly carried out massive air strikes against Iran, particularly the country's military leadership and nuclear facilities. The Israeli government justified the attacks by saying that Tehran was on the verge of creating a nuclear bomb.

Iran responded by attacking Israeli cities, including Tel Aviv, which resulted in civilian casualties, including five Ukrainian citizens on June 14.

U.S. President Donald Trump on June 15 said he was open to the idea of Russian President Vladimir Putin mediating between Iran and Israel.

"He is ready. He called me about it. We had a long talk about it. We talked about this more than his situation (war against Ukraine)," Trump said, according to ABC reporter Rachel Scott.

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The Russian president held separate calls with Iranian President Masoud Pezeshkian and Israeli Prime Minister Benjamin Netanyahu on June 13.

During the call with Iran, Putin offered condolences for what the Kremlin labeled "numerous civilian casualties" and condemned Israel's actions as violations of the UN Charter. He later proposed that Russia could serve as a neutral mediator.

Israel has not commented publicly on the Kremlin's offer, but Peskov's statement implies Tel Aviv's rejection. France has also dismissed the idea, with President Emmanuel Macron saying on June 15 that Moscow "cannot be a mediator."

Russia's ties with Iran have deepened since the start of its full-scale invasion of Ukraine in 2022. Tehran has supplied Moscow with thousands of Shahed attack drones and ballistic missiles used in daily strikes against Ukrainian cities and infrastructure.

Israel, which has historically maintained cautious relations with Russia and is home to a significant Russian-speaking population, has not joined Western sanctions against Moscow.

As of June 16, Iran's Health Ministry claimed 224 people had been killed by Israeli strikes, with Tehran alleging that 90% of the casualties are civilians.

The figures have not been independently verified. Israel has not confirmed casualty numbers but maintains that the strikes were aimed at preventing an existential threat.

On June 13, Kyiv expressed support for Israel, describing Iran as a "source of instability in the region and beyond," citing Tehran's extensive military cooperation with Russia.

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